Dermatologicals

Description

1. Fluconazole is a member of the bis-triazole antifungal agent. Fluconazole is a highly selective inhibitor of fungal cytochrome P-450 sterol C-14 alpha demethylation. Mammalian cell demethylation is much less sensitive to Fluconazole inhibition. The subsequent loss of normal sterols correlates with the accumulation of 14 alpha-methyl sterols in fungi and may be responsible for the fungistatic activity of fluconazole.
2. Fluconazole is well absorbed and oral absorption is not affected by concomitant food intake. Fluconazole has been found to achieve good penetration into all tissues and body fluids studied. The levels of fluconazole in saliva and sputum are similar to plasma levels.
3. The long plasma elimination half-life provides the basis for single dose therapy for vaginal candidiasis.
4. Fluconazole exhibits in vitro activity against Cryptococcus neoformans and Candida species. Activity has been demonstrated in vivo in normal and immunocompromised animals against infections with Candida species, including systemic candidiasis and in normal animals with C. neoformans, including intracranial infections. The efficacy of fluconazole in vivo is higher and would be apparent than in vitro testing against the above-mentioned fungi.

Indications

SURFAZ-O^® Tablets is given orally and is indicated for vaginal candidiasis.