GR8® Capsules

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Composition:

Each hard gelatin capsule contains:        

  • Omeprazole I.P. .................................................……… 20 mg.    

 

(as enteric coated pellets)        

  • Domperidone I.P. ..........................................…...……. 10 mg.

 

(as pellets)

  • Excipients ..........................................................…………. q.s    
  • Colour: Titanium Dioxide I.P.        
  • Approved colour (Titanium Dioxide I.P.) used in empty capsule shells.

Description

  • Gastroesophageal reflux disease (GERD) is one of the commonest problems faced by clinicians in their day-to-day practice. Besides life style modifications and general measures, inhibition of gastric acid secretion with prokinetic gastrointestinal agents can help prevent reflux and have an important role to play in the management of GERD.
  • Omeprazole is a substituted benzimidazole, which inhibits the secretion of hydrochloric acid in the stomach by specific blockade of the proton pumps of the parietal cells. Since Omeprazole binds to the enzyme distal to the cell receptor level, it can inhibit hydrochloric acid secretion independently of the stimulation by other substances (acetylcholine, histamine, and gastrin).
  • Domperidone is a dopamine antagonist with anti-emetic properties. Its antiemetic effect may be due to a combination of peripheral (gastrokinetic) effects and antagonism of dopamine receptors in the chemoreceptor trigger zone, which lies outside the blood-brain barrier in the area postrema. Studies in humans have shown oral domperidone to increase lower oesophageal pressure, improve antroduodenal motility and accelerate gastric emptying. There is no effect on gastric secretion.

Indications

In the management of:

  • Gastro esophageal reflux disease (GERD)
  • Erosive esophagitis
  • Gastric and duodenal ulcers
  • The relief of the symptoms of nausea and vomiting, epigastric sense of fullness, upper abdominal discomfort and regurgitation of gastric contents.