Respiratory

Description

• Acebrophylline is a compound which has been found to act as a bronchodilating, mucoregulating and anti-inflammatory drug due to its components; theophylline-7-acetate and ambroxol. Theophylline-7-acetate, as with other xanthinic derivatives, has a bronchodilator effect due to the inhibition of intracellular phosphodiesterases, followed by an increase in adenosine monophosphate cyclic levels, which promotes relaxation of bronchial muscles. 
• Ambroxol modifies the mucous gel phase of secretions by decreasing the viscosity and increasing the serous gel phase. It increases the mucociliary clearance by stimulating cilia motility.
• Acebrophylline inhibits phospholipase A2 and phosphatidylcholine leading to lesser production of the powerful pro-inflammatory substances like leukotrienes and tumor necrosis factor. By inhibiting the synthesis and release of these inflammatory mediators, acebrophylline reduces inflammation, a key factor in airway obstruction, especially in chronic disease.

Indications

• A-PHYL^™ Capsule is indicated for the treatment of chronic obstructive pulmonary disease, bronchial asthma and bronchitis.